mutation has occurred in the DNA binding sequence for p53. The
binding site is Pu-Pu-Pu-C-A/t-T/a-G Py-Py-Py; and is converted to
Pu-Pu-Pu-T-A/t-T-A/t-T/a-G Py-Py-Pu in the promoter of the Mdm2
gene. What base would be methylated? What would be the effect of
such a mutation on methylation ? What could be the effect of such a
mutation on p53 binding? And, why? How would the expression of Mdm2
be affected ?