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3. A case–control study of Alzheimer’s disease and exposure within the past five years to homecare...

3. A case–control study of Alzheimer’s disease and exposure within the past five years to homecare products that contain aluminum will be conducted. Information about the use of products will be gathered via an in-home survey.

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Answer #1

ALUMINIUM is a silvery white metal which are widely used for household purposes in various types.

  • It doesnt undergo any redox reactions when compared to other metals.
  • Aluminium containing products has been closely linked to various neurological disorders,of which one among is Alzheimer's.
  • When the blood brain barrier is compromised with age, metals like aluminium which are mostly confined to circulation,enter the brain.
  • Once inside the brain,aluminium has the capability to potentiate ROS( reactive oxygen species) and activate glial cells.
  • As this process progresses, an inflammatory reaction is initiated.
  • This inflammatory reaction,is the primary cause of neurodegeneration, thereby leading to the disease.
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