Question

What induces T-cell suppression?

What mediates T-cell suppression?

Oral tolerance—

What sites play an important role in immune privilege?

Answer 1

T- cells mediated immune response is suppressed by the secretion of immunosuppressive cytokinins. This mechanism is mediated by Regulatory T cell or Tregs.

Tregs are specialised subpopulation of T-cells and can inhibit T-cell proliferation and plays a crucial role in immune homeostasis.

Oral tolerance is the state in which there will be local and systemic immune unresponsiveness that may be induced by oral ingestion of antigen such as food protein.

Immune privilege sites are anatomical areas that are naturally shows less immune response than other areas of the body. Main sites are brain,eyes and testes.