Question

Alteplase is a protein drug and has a potency of 580,000 International Units (IU) per milligram protein. How many milligrams of alteplase are required to prepare a 50 mL solution with a strength of 58,000 units/mL?

Answer 1

Required to prepare 50ml solution

1ml --------------------- 58000 units

50 ml---------------------?

50×58000÷1=2900000 units

So prepared 50ml solution contain 2900000 units.

Given that

1mg alteplase protein contain 580000 units

For preparation of 50 ml solution with strength of 2900000 unit (1ml contain 58000 units) we need 5 mg alteplase protein.

580000-------------------1mg alteplase protein

2900000----------------------?

2900000×1÷580000=5mg alteplase protein

Ans:-5mg alteplase protein is required