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A 14-year-old girl suffering from seasonal rhinitis started a therapy with Loratadine (Claritin), a drug that...

A 14-year-old girl suffering from seasonal rhinitis started a therapy with Loratadine (Claritin), a drug that binds to H1 histamine receptors. How would you describe the relationship between Loratidine (Claritin) and the histamine receptor? (select all that apply)

            a. Loratidine (Claritin)  is an agonist for the H1 receptor

            b. Loratidine (Claritin)  is an antagonist for the H1 receptor

            c. The H1 receptor binds to Loratidine (Claritin)

            d. Loratidine (Claritin)  is a partial agonist for the H1 receptor

            e. Histamine is an agonist for the H1 receptor     

            f. Histamine is an antagonist for the H1 receptor

            e. Histamine displays efficacy on a dose response curve

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Answer #1

Options b and e.

a. Loratadine (Claritin) is an agonist for H1 receptor: Incorrect

b. Loratadine (Claritin) is an antagonist for H1 receptor: Correct

c. The H1 receptor binds to Loratadine: Incorrect – Loratadine interferes with the agonist activity of histamine at the H1 receptor thereby relieving allergic symptoms.

d. Loratadine is a partial agonist for the H1 receptor: Incorrect

e. Histamine is an agonist for the H1 receptor: Correct

f. Histamine is an antagonist for the H1 receptor: Incorrect

g. Histamine displays efficacy on a dose response curve: Incorrect – Loratadine displays the curve.

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