Question

provider orders oxaliplatin 225 mg/m2, IV, one dose now. The patient weighs 67 kg and is 151 cm in height. The pharmacy provides oxaliplatin in vials containing 5mg/ml

Answer 1

Step 1:Calculation of BSA using Mostellers equation

BSA (in m^{​​​​​2}) = (Height in cm *weight in kg/3600)^1/2

That is (151*67/3600)^1/2

^​​​​=(10117/3600)^1/2 = (2.81)^1/2 = 1.67 ^m2

Step 2:Calculation of dose required for the patient based on BSA

By using proportion,

1m² corresponds to 225 mg

Therefore 1.67m² requires 225*1.67=375.75 mg

Step 3:Calculation of ml to be taken for IV administration

Strength of vial= 5mg/ml

Required dose=375.75mg

Therefore ml to be withdrawn =375.75/5=75.15 ml