Question

A vaccine company working on an inhaled COVID19 vaccine wants to assure that B cells and T cells form cognate pairs so that a germinal center will ultimately be formed.
A. What signals will the SARSCoV2-reactive TFH and B cell need to form a cognate pair?
B. In a research animal, where would you find this cognate pair together (specific anatomical location)?

Answer 1

A) The severe acute respiratory syndrome coronavirus 2(SARS_CoV_2) pandemic dramatically widespread all over the world. Also made many significant changes in the earth.

Today the world looking forward for vaccines and remedies, which can drop the virus. The studies says that the germinal center (GC) can be pathogenic Hotspot for the production of antibodies in autoimmune diseases. High _affinity B cells and Follicular helper T (TFH) cells shows their location in GCs and thus GC formation.

It shows that S _specific antibodies, B_cells and cTFH are consistently elicited after SARS_CoV_2 infection, which robust humoral immunity and positively associated with plasma neutralizing activity.

B) Lymph nodes where, the cognate pairing of B cells and Follicular helper T cells happening.