Question

1. Select the best answer:
   1. Randomized controlled trials are considered the “gold standard” of epidemiology study designs because randomization guarantees comparability of study arms.
   2. A weakness of randomized controlled trials is that they are prone to misclassification of exposure status.
   3. It is difficult to perform intention-to-treat analyses with randomized controlled trials.
   4. Randomized controlled trials are observation studies because study arms are observed for outcomes.
   5. Randomized controlled trials are not an effective study design for assessing rare outcomes.

Answer 1

Correct answer is option(A) Randaomized controlled trials are considered the “ gold standard “ of epidemiology study designs because randomization guarantees comparability of study arms.

A randomized controlled trial is a type of scientific (often medical) experiment that aims to reduce certain sources of bias when testing the effectiveness of new treatment; this is accomplished by randomly allocating subjects to two or more groups,treating them differently,and then comparing them with respect to a measured response.

The randomized controlled trial and,especially,systematic reviews of several of these trials are traditionally the gold standards for judging the benefits of treatments,mainly because it is conceptually easier to attribute any observed effect to the treatments being compared.