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Which of the following determine the degree of movement of a pharmacological agent between compartments of...

Which of the following determine the degree of movement of a pharmacological agent between compartments of the body?

A. Partition constant

B. Degree of ionization

C. Size

D. pH

E. All of the above

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Answer #2

Answer is E. All of the above.

The degree of movement of a pharmacological agent between compartments of the body depends on

  • Partition constant: It is the ratio of the solubility of the agents. It is useful in determining the distribution of drug inside the body. It is used for determining the drug quality.
  • Degree of ionization: It determines the strength of the agents.
  • Size: The size of the agents will determine how the agent will pass through the body and meet the target point for its action. The larger the agent, the more difficult it will be for the patient to swallow.
  • pH: The pH of the agent should be from 1 to 8 so that ionization will take place .
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