Question

When two antimicrobial drugs are used at the same time, antagonistic effects can occur. Which of...

When two antimicrobial drugs are used at the same time, antagonistic effects can occur. Which of the following is NOT a possible antagonistic effect of combining two antimicrobial drugs?

Select one:

a. Increased activity of both drugs

b. Decreased therapeutic levels

c. Increased elimination of one drug

d. Increased toxicity

e. Decreased activity of both drugs

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Answer #1

ANS : a) Increased activity of both drugs.

Explanation: Antagonistic interactions produce harmful effects.

Antagonistic Occurs when two antimicrobials prescribed at the same time. Antagonistic effects vary in different conditions and the use of drugs.

It may cause: 1.Loss of drug activity.

2.Decreased therapeutic levels due to increased metabolism and elimination.

3.Increased potential for toxicity (Due to decreased metabolism and elimination).

4.Decreased activity of both drugs. For eg., some antibacterial are absorbed easily from the acidic environment of the stomach, if a client prescribed with antacids, it increases pH of the stomach and generates negative impacts the absorption of the antimicrobial drug, decreasing their potential in treating an infection.

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