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K.J. is a 17-month-old Winnebago Indian female who is brought to her pediatrician by both parents....

K.J. is a 17-month-old Winnebago Indian female who is brought to her pediatrician by both parents. The patient has had a 24-hour history of fever, irritability, crying, tugging at both ears, and significantly decreased appetite. Her mother reports that K."s temperature last evening was 101 degrees F and that she had difficulty sleeping despite taking ibuprofen. Mom also reports taking the child to the nurse practitioner nine days ago with cough, runny nose, and apparent earache and receiving a prescription for Pediazole. "There have been colds going around the daycare center," she informs the doctor. She has been very conscientious about giving K. her Pediazole three times a day for the past nine days. Past Medical History: Former 40-week 8 lb-1 oz infant delivered vaginally; uncomplicated prenatal course; Apgar scores WNL; was breast-fed and supplemented with formula; no surgeries or hospitalizations; immunizations are current; one episode of pneumonia at age 14 weeks; recurrent AOM x 5 during the past 14 months; most recent episode 9 days ago and currently receiving treatment with Pediazole; patient has previously received both cephalosporins and macrolides for AOM; only adverse effect has been significant diarrhea with Augmentin. Questions: 1. Which two antibacterial medications are combined in Pediazole and why is this drug appropriate for treating acute otitis media? 2. Which two antibacterial medications are combined in Augmentin and why is this drug appropriate for treating acute otitis media?

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Answer #1

1. Pediazole

It is the combination of Erythromycin and sulfisoxazole. This product contains a macrolide (erythromycin) and a sulfa-type (sulfisoxazole) antibiotic. It works by stopping the growth of bacteria. Hence it used in the treatment of acute otitis media.

2. Augmentin

Augmenting is Amoxicilline and clavulanate potassium combination. It is  is a combination penicillin-class antibacterial and beta-lactamase inhibitor indicated in the treatment of infections due to susceptible isolates of the designated bacteria in the conditions. Acute otitis media is Caused by beta lactamase–producing isolates of H. influenzae and M. catarrhalis.

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