Question

Name a drug of abuse whose biochemical action in the brain is most similar to that of each of the neurotransmitters listed below. In other words, the drug has a special affinity for acting in the same neural pathways and target the same receptors of the neurotransmitter. (Note:All drugs have multiple effects, but they usually have a primary, direct effect that contributes to its unique biochemistry. You should not have to use the same drug twice.)

Explain your choice in a sentence or two.

a. dopamine

b. GABA

c. norepinephrine

d. serotonin

e. endorphin

f. acetylcholine

g. anandamide

Answer 1

a. dopamine - Cocaine (inhibit the dopamine reuptake and increase the DA availability)

b. GABA - Barbiturates (induces sleep by enhancing GABA transmission (inhibitory))

c. norepinephrine - Atomoxetine (inhibit NE reuptake and causes stimulation, used for its stimulant effect)

d. serotonin - Zoloft (serotonin uptake inhibitor, used as an anti-depressant, abused for its stimulant effect)

e. endorphin - Morphin (narcotic drug, which causes muscle relaxation and induces sleep, it is abused for these effects)