Question

29. Oxybutynin (Ditropan) is prescribed for a client diagnosed with an overactive bladder (OAB). The client reports having experienced numerous adverse effects with the immediate-release tablets (Ditropan-IR). The client asks the nurse how the transdermal patch could cause less adverse effects if it is essentially the same drug. The nurse’s response should be based on the knowledge that: a. Transdermal absorption bypasses metabolism in the intestinal wall. b. The transdermal form is water soluble and poorly absorbed. c. The transdermal form is a different drug than oral oxybutynin. d. The transdermal form is less effective than the extended-release (ER) oral form. 30. Poisoning by reversible cholinesterase inhibitors can be treated by administration of what drug? What is the action of this drug that reverses the symptoms?

Answer 1

Transdermal patch consist of delivering the medication through the skin, in a non-invasive manner. The patch is placed on the skin anywhere it needed, and slowly the absorbtion of the medication takes place directly to the circulatory system through the blood vessels.. The Transdermal absorption bypasses the metabolism in the intestinal wall as it gets directly absorbed through the blood vessels beneath the skin. So, The correct answer is (a).

* The poisoning by reversible cholinesterase inhibitors can be treated by administration of the durg Pralidoxime. This can be administered within 48 hours of poisoning.