Question

Description The Hypothalamic-Pituitary Axis is responsible for a wide variety of normal physiologic functions. It is essential to have a firm understanding of how the normal feedback loop works in order to understand alterations involving the Hypothalamic-Pituitary Axis. The purpose of this assignment is to demonstrate understanding of the normal feedback regulation of the Hypothalamic-Pituitary Axis and recognition of alterations in normal regulation. Instructions Compose a short (1 – 4 pages) essay explaining the role of the Hypothalamic-Pituitary axis and normal feedback function, including both positive and negative feedback. As part of your essay, include examples of failed feedback and explain how this leads to altered physiologic functioning. The essay should be structured, and follow a logical format.

Answer 1

The hypothalamic pitutary adrenal axis is our central stress response system.ACTH binds to receptors on the adrenal cortex and stimulates adrenal release of cortisol.In response to stressor ,cortisol will be released for several hours after encountering the stressor.The system works in a straight forward manner.This response is characterised by hypothalamic release of corticotropin releasing factor.CRF also known as CRH or corticotrophin hormone .When stress happens the cortisol will be relesed into the body at a certain concentraion of cortisol this protection is acheived by cortisol negative feedback to the hypothalamic relewase.The negative feedback loop taht operate in the hypothalamus pitutayry endocrine axis provide some insight into how the hypothalamus maintains the body internal environment.