Thiazide antihypertensive drugs like hydrochlorothiazide are known to suppress the response to peroxisome proliferator-activated receptor gamma. By this it significantly reduces the release of insulin while activating the reninangiotensin-aldosterone system at the same time and hence raises the levels of aldosterone which is a hormone responsible for stimulating the absorption of sodium by the kidneys. This alteration causes hyperglycemia.
As far as hyperlipidemia is concerned, there is no scientifically proven explanation to this but it believed that it happens as the thiazide diuretics causes significant depletion in the levels of potassium and sodium in the body.
Get Answers For Free
Most questions answered within 1 hours.