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Lysergic acid diethylamide (LSD) is the prototype of the hallucinogenic drugs. What is the likely mechanism...

Lysergic acid diethylamide (LSD) is the prototype of the hallucinogenic drugs. What is the likely mechanism of action of these drugs?

A) They interact with serotonin receptors and disrupt normal brain activity

B) They block serotonin receptors and contribute to cycles of mania and depression

C) They interact with norepinephrine receptors and disrupt normal brain activity

D) They block norepinephrine receptors and contribute to cycle of mania and depression

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Answer #1

Lysergic acid diethylamide (LSD) is the prototype of the hallucinogenic drugs. The likely mechanism of action of these drugs is;

A) They interact with serotonin receptors and disrupt normal brain activity (LSD mainly works by the activation of serotonin receptors (namely 5HT2A receptors or 5hydroxytryptamine 2A receptor, 5-HT2AR) with the modulation of the 5HT2C and 5HT1A receptors. The interactions between the receptor activation leads to the impairment in cognition and induction of hallucinations

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