Question

Patient recently has diagnosed with gaut. Which of these drug regimens is most appropriate for management of the previous patient?

a.	Xanthine oxidase inhibitor therapy with allopurinol or febuxostat

b.	A starting dosage of allopurinol >100 mg/day

c.	A starting dosage of allopurinol at 300 mg/day

d.	A fast upward titration of the maintenance dose of allopurinol

Answer 1

TREATMENT OF GOUT:-

The drug of choice for primary gout is allopurinol,which competitively inhibits the enzyme xanthine oxidase. this type of inhibition is referred as SUICIDE INHIBITION. Inhibition of xanthine oxidase by allopurinol leads to accumulation of hypoxanthine and xanthine, which are more soluble than uric acid. Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates.

The usual starting dose of allopurinol is between 100 mg and 300 mg daily, so the options b and c are wrong.

Correct option: A. Xanthine oxidase inhibitor therapy with allopurinol or febuxostat.