Question

?Order: DTIC-Dome? (dacarbazine) 250 ?mg/m2 IV for 5 days. The label on the vial states to reconstitute with 9.9 mL of sterile water for? injection, yielding a strength of 10? mg/mL, further dilute in 250 mL of? D5W, and infuse over 60 minutes. Calculate the rate of flow in milliliters per hour for a client who weighs 70 kg and is 180 cm tall.

Answer 1

Order dose dacarbazine 250 mg/m2 IV for 5 days.

Formula to calculate BSA(Mosteller) = √(Weight In kg Height in Cm) 3600

= √(70kg 180 cm ) 3600

= 1.87 m2

Then dose will be

250 mg/m2 1.87 m2 = 467.5 mg

Then we need 468 mg of drug.

We have a drug concentration of 10 mg/ml

so we need

Further, it will be diluted in 250ml D5W so, the total solution will be 296.8 ml(297 after rounding) and it will infuse over 1 hour.

Answer - The flow rate will be 297 ml/hr