Question

Fred is taking 1000mg penicillin, which has a short half life of 1.5h. Doses occur at...

Fred is taking 1000mg penicillin, which has a short half life of 1.5h. Doses occur at six hour intervals. How much penicillin is in his bloodstream six hours after his first dose?

Select one:

A. 62.5mg

B. 31.25mg

C. 125mg

D. 250mg

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Answer #1

Answer A.62.5mg

Half life = 1.5 hours

Time given = 6 hours = 6/1.5 = 4 (four)half lifes

Half life of a drug is the time taken for the plasma level of drug to reduce by 50% .

After first half life ,drug level = 1000*50% = 500

After second half life ,drug level = 500*50/100 = 250

After third half life, drug level = 250*50/100 = 125

After fourth half life ,drug level = 125*50/100 = 62.5

Hence after 6 hours ,4 half lifes, penicillin in bloodstream would be 62.5mg

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