Question

Describe the pathological joint changes associated with Osteoarthritis. Describe the articular cartilage and explain how focal inflammation will erode the cartilage, leaving bone-on-bone contact. This contact stimulates the inflammatory response, resulting in disease progression.

Answer 1

Pathological joint change associated with osteoarthritis are :-

- progressive loss and destruction of articular cartilage .

- subchondral bone thickness .

- osteophytes formation .

- synovium inflammation .

- hypertrophy of joint capsule.

- ligament degeneration .

Articular cartilage :- this is an smooth white tissue that covers the end of bone where they come together to form joints . That helps our joints to move easier and comfortable . articular cartilage can be damaged by injury or normal wear and tear .

Focal inflammation will erode the cartilage in which inflammation attacks joint and tissue and can cause joint swelling , increase joint fluid , bone and cartilage damage , and muscles loss . Nerve also activated and causes pain . Inflammatory chemical also activates other nerves of body and leads to pain . Bone erosion also appears as pre inflammatory action .