Question

List three (3) RBC inclusions that could be confused with reticulocytes on a reticulocyte smear. Q7....

List three (3) RBC inclusions that could be confused with reticulocytes on a reticulocyte
smear.

Q7. State how you would differentiate each RBC inclusion mentioned in Question 6
above from reticulocytes.

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Answer #1

The most common RBC inclusions are Howell-Jolly bodies,Pappenheimer bodies,Heinz bodies and basophilic stippling

Pappenheimer bodies-Abnormal basophilic granules of iron found inside red blood cells on routine blood stain.

Basophilic stipping-Inclusions in a RBC that are composed of aggregates of ribosomes; degenerating mitochondria and siderosomes.

Howell-Jolly bodies-Afinding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes.

During maturation in the bone marrow, late erythroblasts normally expel their nuclei,but in some cases a small portion of DNA remains.

7)Adjusting fine focus ,size,re-staining can use to differentiate each RBC inclusion from reticulocytes.

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