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Which of the following increases the efficacy of hemodialysis in treating drug overdose but decreases the...

Which of the following increases the efficacy of hemodialysis in treating drug overdose but decreases the total extent of drug removal during hemodialysis? 1. Large drug distribution volume 2. Decreased intercompartmental clearance during hemodialysis 3. Decreased protein binding 4. Increase in blood flow through dialyzer 5. Extensive drug partitioning from plasma into erythrocytes

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Answer #1

It is due to decreased protein binding.The drug overdose decreases the total extent of drug removal during hemodialysis as primary binding proteins for most drug are of large molecular size ,due to this the drug protein complex is often too large to cross the dialysis membrane especially in case of hemodialysis.The peritoneal membrane does permit the passage of some proteins limiting the drug overdose and decreasing its extent.It is dependent on the factor determining the drug dialyzability.

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