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Pharmacogenomics can explain, and prevent, deaths from A. Reduced TPMT activity in patients receiving 6-MP B....

Pharmacogenomics can explain, and prevent, deaths from A. Reduced TPMT activity in patients receiving 6-MP B. Increased TPMT activity in patients receiving 6-MP C. Increased CYP 2D6 activity in patients receiving codeine D. Reduced CYP 2D6 activity in patients receiving codeine

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Answer #1

Thiopurines are frequently used to treat childhood acute lymphoblastic leukemia. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that inactivates thiopurine drugs such as 6-mercaptopurine and azathioprine through methylation.

Low TPMT activity levels could put a patient at risk for developing toxicity. the cytotoxic active metabolite incorporated into DNA. a patient with high TPMT activity levels would need higher than standard doses of a thiopurine drug to respond well to the therapy, since a large amount of the drug is being inactivated before it can be converted to 6-TGNs.

Correct option: A. Reduced TPMT activity in patients receiving 6-MP

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