A voxel may be a single sample, a data point, on a regularly spaced, three-dimensional grid. Voxels re made use of in medical science for visualisation, analysis and interpretation of scientific medical data. Voxels usually represent a single point rather than the volume. It is used in Computerized tomography, where opacity of anatomical structures are provided to X rays. In CT, I is represented as Hounsfield units.
Voxel based dose optimization is necessary for intensity modulated radiation therapy (IMRT) as it has low planning efficiency and large plan quality uncertainty in clinical practice. Studies done to automate this process have ignored the fact that organ-based objective functions used in treatment planning systems (such as dose-volume function) usually lead to sub-optimal plans.
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