Question

1. Order: vinblastine sulfate 3.7 mg/m^2 IVP infuse over one minute once a week. The patient’s BSA is 166 m^2. The package insert states to reconstitute the 10 mg vial with 10 ml NS, yielding a concentration of 1 mg/ml.

How many of this antineoplastic drug will the patient receive?

How many milliliters contain the dose?

How many milliliters will you push every 15 seconds?

Answer 1

Vinblastine sulphate is a drug which is mainly used as a treatment for cancer. Order of drug is 3.7mg/m^2 IVP which indicates that the patient is receiving the first dose of medicine.Usually the dose of drug will be increased by 1.85mg/m2 per week until the patients WBC count reaches 3000/mm3.

The vial contains 10mg and the dilution is in 10 ml NS.So each ml contains 1mg of drug.As per order 3.7 ml to be administered over one minute once a week.(1ml=1mg,3.7ml=3.7mg)

Drug should be administered in 15 seconds=0.925 ml (3.7/60x15) or( 3.7/4)

.93 ml can be givento the patient as ivp over 15 seconds .