Question

Pathogenesis of osteo and rheumatoid arthritis

describe the classes of anti-dysrhythmic drugs relating to modify the cardiac rhythm

Answer 1

Rheumatoid arthritis is assoocciated with both localized and generalized osteoopososis, localized oeteoporosis can be considered to be caused by local disease mechanism including the generation of factors from activation of the cytokine pathway.The etiology of generalized osteoporosis has been difficult to elucidate,particularly because of the lack of sensitive techniques to measure bone mineral density.Igeneral mineral density loss at appendicular sites does not correlate with axial bone density loss.

Classification of anti dysrhythmic drugs,

Class 1 agents interfer with the sodium channer

Class 2 agents are anti sympathetic nervous system agents

Class 3 agents affects potassium efflux

Class 4 agents affects calcim channel and the AV node

Class 5 agents work by other or unknown mechhanisms