Question

10. Which of the following statements correctly pairs an antiasthmatic drug with the molecular action that can explain its effect?

A. Cromolyn - blockade of leukotriene receptors

B. Tiotropium - blockade of M2 receptors

C. Corticosteroids - blockade of adenosine receptors

D. Albuterol - stimulation of adenylyl cyclase

E. Omalizumab – inhibition of PDE4

11. A 55-year-old woman with chronic asthma is reasonably well controlled on oral theophylline and inhaled albuterol. She now presents with an upper respiratory tract infection and is prescribed erythromycin. An appropriate change in the patient’s therapeutic regimen would be to:

A. add inhaled dexamethasone.

B. add oral prednisone.

C. decrease the dose of theophylline.

D. change the dose of albuterol.

E. add inhaled cromolyn sodium.

12. A 56-year-old male presents with chronic mucoid cough and breathlessness of 1-year duration. He has an 80 pack-year smoking history and currently smokes 1 pack/day. Spirometry shows an FEV1 of 50% of the predicted value. The physician decides to start therapy with ipratropium through a metered dose inhaler. Which of the following receptors would be blocked in this patient?

A. Nn

B. M3

C. IgE

D. H1

E. cysLT1

Answer 1

10. Cromolyn does blockade of leukotriene receptors.

Mechanism of Action: An antiasthmatic that binds to cysteinyl leukotriene receptors, inhibiting the effects of leukotrienes on bronchial smooth muscle. Therapeutic Effect: Decreases bronchoconstriction, vascular permeability, mucosal edema, and mucus production.

13. M3 - ipratropium are antagonists of three muscarinic receptor subtypes: M1, M2, and M3.In patients with COPD, increased parasympathetic nervous system activity leads to bronchoconstriction and mucus secretion. Anticholinergic agents induce relaxation of airway smooth muscle.