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5. Sadie has been taking indomethacin as part of therapy for osteoarthritis but lately has noticed...

5. Sadie has been taking indomethacin as part of therapy for osteoarthritis but lately has noticed that it has been less effective. Her health care provider has decided to try celecoxib (Celebrex). Sadie has a history of hepatitis (15 years ago).

a. What advantages might there be to treatment with celecoxib rather than indomethacin?

b. What potential adverse effects should the nurse warn Sadie about before she takes this drug?

What should the nurse report to the health care provider?

c. Sadie asks the nurse if she can drink her usual glass of wine each evening while on this drug. What does the nurse tell her?

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Answer #1

Answer: Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. Celecoxib may improve rheumatoid arthritis symptoms and alleviate pain more than placebo.

The nurse should inform the patient about the side effects of the medicine such as:

  • Celebrex may cause serious stomach and intestinal ulcers
  • headache,
  • abdominal pain,
  • indigestion,
  • diarrhea,
  • nausea,
  • upset stomach

The nurse should warn Sadie that she should not take the wine as it will make her liver worse and will increase the pain. As she is having history of hepatitis, she should avoid all those things which causes liver to be damaged more.

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