Question

knowing that clostridium perfringens is an endospore-forming bacteria, is it possible that treatment of one's leg wound with alcohol would prevent infection with clostridium perfringens?

Answer 1

An endospore is a tough resistant, protective layer, which keeps the cell in the dormant state under unfavorable conditions of growth. For example, in tundra soils, the bacteria form endospores during the cold summers and become active during the warm summers when the temperature allows their active metabolism.

Alcohol acts as an antiseptic and disinfectant by the disruption of lipid membranes and leakage of cellular components. It cannot act against the endospores, so, it would not prevent infection with clostridium perfringens.