Question

What is used to describe the effect of drugs in disease progression models? 1. Symptomatic benefit models 2. Square root models or 3. Drug interaction models?

Answer 1

Disease progression modeling involves the utilization of mathematical functions as quantitative descriptors of the time course of disease status. Disease models may incorporate biomarkers ofdisease severity and/or clinical outcomes to characterize the natural progression of disease.

Symptomatic benefits model is the clinical benefit response as the disease progresses overtime which is used to describe the effects of drug used for the disease.

Example: Few reports on use of symptomatic benefits as an alternative or adjunctive for the assessment of objective response in chemotherapy of the advanced cancer.