Question

_____8. For a drug with high first pass effect, which of the following dosage forms should be avoided? a. Oral tablet b. Sublingual tablet c. Transdermal preparation d. Rectal suppository _____9. Drug X has an elimination half life of 80 hours and oral bioavailability of 100%. After oral administration, the steady state concentration is expected to be attained in: a. 8 days b. 4 days c. 10 days d. 14 days _____10. Time it takes a drug to begin working a. Duration b. Onset c. Rate of absorption d. Half life _____11. This is a type of drug metabolism wherein the drug is reduced or oxidized through the use of a polar group. a. Phase I reaction b. Phase II reaction c. Phase III reaction d. Liver microsomal drug oxidation/reduction _____12. This is a type III AED. a. Phenytoin b. Phenobarbital c. Ethosuximide d. Valproic acid _____13. These are all direct sympathomimetic non catecholamines except: a. Phenylephrine b. Albuterol c. Terbutaline d. Dopamine _____14. These are all direct sympathomimetic catecholamines except: a. Phenylephrine b. Epinephrine c. Dobutamine d. Dopamine

Answer 1

8. First Pass effect or presystemic metabolism whereby the concentration of a drugs is greatly reduced before it reaches the systemic circulation. so its best to avoid Oral route of administration in drugs with high pass effect

9.4days when the oral bioavailability is more steady state will reach faster

10. time taken for the drugs to begin working is Onset

11.Phase I reaction is in which the drugs metabolism where in drug is reduced with the use of polar group

12. Valporic acid is type 3 AED

13. Among the other noncatacholamine drugs dopamine is a catacholamine group

14.Phenylephrine belongs to non catacholamine drugs