Question

which of the following leads to greater insulin release/production as its primary mechanism>

a. pioglitazone

b. sitagliptin

c. Extendatide

d. B & C

e. All of the above

Answer 1

Answer- Pioglitazone is a Thiazolidenediones with primary mechanism of action of decreasing insulin resistance and increasing Uptake of glucose by peripheral tissues.

Sitagliptin- It is a DPP-IV (Dipeptidyl Peptidase) inhibitor so it's primary mechanism of action is inhibition of DPP-IV thus prolonging life of Glucagon like peptides in gut which help in reducing gastric emptying and further increases the insulin secretion in response to meals.

Exenatide- It is a recombinant Glucagon like peptide(GLP) analogue. GLP is normally secreted (in GIT) when food enters the stomach and it stimulates release of insulin.

As asked in question which leads to greater insulin release as it's primary mechanism so Answer must

C.) Exenatide.

Sitagliptin also increases insulin release but it is not it's primary mechanism of action.