Question

JJ is a 55-year-old patient with complaints of persistent vaginal dryness and dyspareunia. She has minimal risk factors for the addition of hormone therapy. She denies hot flushes or sleep disturbances. The best treatment option for JJ is:

estradiol 0.01% [Estrace] vaginal cream

conjugated equine estrogen [Premarin]

conjugated equine estrogen plus medroxyprogesterone acetate [Prempro]

estradiol 0.1 mg/d [Vivelle] transdermal patch

Answer 1

estradiol 0.1mg/d(vivelle)transdermal patch
Transdermal patch with estradiol is a hormone replacement therapy that work through the skin, that best suit for women after 55 years by lowering side effects than oral estrogen therapy.
  estrace treats moderate to severe vasomotor symptoms associated with menopause, it also prevent bone loss and cancer. it can be used as an initial dose to treat the symptoms. it has low side effects.
   low serum estrogen level during menopause causes vaginal estrogen deficiency Conjugated equine estrogen plus medroxyprogesterone acetate(Prempro) in a combination for treating menopause symptoms like hot flushes and vaginal changes that prevent osteoporosis. but this patient not having symptoms of hot flushes.