Question

Explain how prostaglandins play a role in causing the pain and inflammation of osteoarthritis and rheumatoid arthritis.

Answer 1

Prostaglandins are an inflammatory mediators which is produced by the arachidonic acid (AA) from the membrane phospholipid and by the enzyme named phospholipase. Eventually the enzyme Cyclooxygenase and prostaglandin synthase metabolizes the arachidonic acid (AA) to prostaglandin which play very important role in the modulation in physiological system for example Central nervous system, inflammatory and immune responses. The enzyme named Lipoxygenase (LOX) activates the oxidation chemical reaction which converts Arachidonic acid into prostaglandins which in turn results in pain and inflammation.