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Which of the following antibiotics inhibit DNA gyrase? Nadlidixic acid ciporofloxacin penicillin both A and B

  1. Which of the following antibiotics inhibit DNA gyrase?

    Nadlidixic acid

    ciporofloxacin

    penicillin

    both A and B
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Answer #1

Antibiotics that inhibit DNA gyrase:

Answer: Both A and B (option D/ 4 )

A : Nadlidixic acid

B. Ciprofloxacin  

Both are quinolone antibiotics, that kills the bacteria by inhibiting the DNA ( deoxy ribo nucleic acid) gyrase, and topoisomerase iv, thus inhibiting bacterial DNA replication .

Option C: Penicillin is an incorrect option, as the mechanism of action of penicillin is inhibiting the transpeptidase ,that is essential for bacterial cell wall synthesis.  

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