Question

A patient arrives in the ED via EMS having a grand mal seizure. The ED physician instructs the RN to give 10 milligrams of Diazepam IV X1 dose STAT. The patient’s seizure breaks within 2 minutes of the Diazepam being administered. The mechanism by which this medication causes rapid resolution of seizure activity is via which receptor type (effector pathway/receptor subtype)?

	A.	Slow effector pathways/G-protein coupled receptor
	B.	Slow effector pathway/ion channel
	C.	Rapid effector pathways/G-protein coupled receptor
	D.	Rapid effector pathway/ion channel

Answer 1

1) C) Rapid effector pathways/G-protein coupled receptor

Diazepam is a benzodiazepines derivative with anti-anxiety, sedative, hypnotic and anticonvulsant properties. Diazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic system and the hypothalamus.
This increases the frequency of chloride channel opening, allowing the flow of chloride ions into the neuron and ultimately leading to membrane hyperpolarization and a decrease in neuronal excitability. So hereThe ED physician instructs the RN to give 10 milligrams of Diazepam IV X1 dose STAT. The patient’s seizure breaks within 2 minutes of the Diazepam being administered action of mechanism is rapid effects with G protein coupled as It leads to membrane hyperpolarization and a decrease in neuronal excitability in patient.