Question

List the molecules involved in dendritic cell activation, migration, and maturation.

Answer 1

Molecules activating dendritic cells: directly by conserved pathogen molecules, indirectly by inflammatory mediators, by cellular stress molecule, by disturbance in milieu interior, cytokines.

Molecules involved in migration of dendritic cells: cell adhesion molecule L1, CCL21, CCL19, Semaphorin 3A, Rho associated protein kinase, CLEC2, TNF, IL-1.

Molecules involved in maturation of dendritic cells- PPRs(TLRs, Clara, NLRs), Transcription factors (NFk-xB, Foxo-3, T-bet).