Question

Why is it necessary for portions of o-factor protein to fi into the major groove? during trascription

Answer 1

the major groove is wider than the minor groove. These grooves allow proteins to bind to and recognize DNA sequences from the outside of the helix. The grooves expose the edges of each base pair located inside the helix, which allows proteins to chemically recognize specific DNA sequences.

a protein that binds to DNA and regulates gene expression by promoting or suppressing transcription

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