Question

What drug can increase a patients chance of overdose when taken with opioids?

a. lisinopril

b. diphenhydramine

c. alprazolam

d. phentermine

Answer 1

Correct option is alprazolam C. Opioid affect the first step of metabolism of alprazolam by inhibiting metabolic pathways which may have profound effect on clearance of the alprazolam level in Body . Sign and symptoms of overdose Are Sleepiness ,confusion, poor coordination , slow reflex ,coma, over sedation , death. That's why. Opioid are contraindicated during alprazolam therapy.

Not others

Other drug do not have interaction with opioids .

Only CNS antidepressants CAN effects the Diphenhydramine not specifically opioids .