Question

risperdal how does it work

Answer 1

Risperidone is an antipsychotic drug used to treat psychosis , schizophrenia and mania .

Risperidone is an second generation antipsychotic

Ways to take it:
Tablets: 0.5mg, 1mg, 2mg, 3mg, 4mg, and 6mg strengths

How it works?

Dopamine called as naturally occurring chemical messenger (neurotransmitters ) in the brain , which involves in thinking , behaviour ,perception and emotions.

In some disease there will too much dopamine is produced and this cause some of the symptoms of illness . Risperidone blocks the effects of dopamine in the brain, resulting in a reduction of the symptoms.

Risperidone is the combination of D2 +5-HT2 receptor blocker .

The primary action of risperidone is to decrease dopaminergic and serotonergic pathway activity in the brain, therefore decreasing symptoms of schizophrenia and mood disorders.

D2 dopaminergic receptors are transiently inhibited by risperidone, reducing dopaminergic neurotransmission, therefore decreasing positive symptoms of schizophrenia, such as delusions and hallucinations

(Schizophrenia is thought to result from an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively.)

Rapid dissociation of risperidone from the D2 receptors contributes to decreased risk of extrapyramidal symptoms (EPS), which occur with permanent and high occupancy blockade of D2 dopaminergic receptors.

In addition, 5-HT2A receptor blockade results in decreased risk of extrapyramidal symptoms, likely by increasing dopamine release from the frontal cortex.Through the above mechanisms, both serotonergic and D2 blockade by risperidone are thought to synergistically work to decrease the risk of extrapyramidal symptoms.

Hence by simply the risperidone is an antipsychotic drug used to treat schizophrenia like illnesses by blocking the effect of dopamine in the brain.