Question

A person recently had heart surgery and was given antibiotics to prevent infection. Two weeks later, the patient began to display symptoms of autoimmunity. What is the most likely cause?

- The patient lacks a thymus.

- Polyclonal B cell activation.

- Release of sequestered antigens.

- All of the answer choices are correct

- Molecular mimicry.

Answer 1

ANSWER) molecular mimicry.

Molecular mimicry, where a foreign antigen shares sequence or structural similarities with self-antigens. Molecular mimicry has typically been characterized on an antibody or T cell level.

autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems.

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