Question

• Which anti-infective is contraindicated in pregnancy? Why?
• Which anti-infective are most likely to cause or exacerbate renal failure in the elderly client?
• Which beta-lactam antibiotics are recommended in the treatment of neonatal meningitis caused by E Coli, H. Influenzae, or Klebsiella?
• Which anti-infective is recognized as clinically important hepatic enzyme inhibitors?

Answer 1

Which anti-infective is contraindicated in pregnancy? Why?

The following are the anti-infectives contraindicated in pregnancy:

i. Aminoglycosides: The Aminoglycosides are antibiotic type of anti-infectives contraindicated for pregnant women. The Aminoglycosides are reported to have an ototoxic effect and increased risk of ototoxicity in the fetus. The fetus has been reported to have an increased risk of kidney and ear permanent damage.

ii. Fluconazole: The Fluconazole are anti-fungal type of anti-infectives contraindicated in pregnancy. The Fluconazole are reported to have cardiac, skeletal and congenital abnormality in children and thus contraindicated during pregnancy and even a single dose has been reported to increase the risk of congenital malformations during pregnancy.

Which anti-infective are most likely to cause or exacerbate renal failure in the elderly client?

Nitrofurantoin are a antibiotic type of anti-infectives that are most likely to cause or exacerbate renal failure in the elderly client. The Nitrofurantoin are contraindicated for the elderly client or geriatric population with low renal clearance below 60ml/min and can lead to increased risk of renal and liver failure in the client with age progression.