Question

Fill in the blank space

1. ..…………………………. is an indirect measure of platelet number and a more direct measure of platelet function, vascular integrity, and platelet interaction with the vascular subendothelium. A. Prothrombin time B. Activated partial thromboplastin time C. Clotting time D. Bleeding time 2. Name three causes of thrombocytopenia

3. Heparin-induced thrombocytopenia is associated with both……… and …………

4. Thrombotic thrombocytopenic purpura (TTP) as a cause of thrombocytopenia is caused by:

5. List two other laboratory findings in TTP apart from thrombocytopenia

6. List four causes of acquired coagulation disorders

7. In the most common type of Von Willebrand disease, there is

8. The following laboratory results were obtained for a patient with an inherited autosomal dominant trait: Platelet adhesiveness – abnormal, PT – normal, APTT - normal, bleeding time – prolonged. These findings are most consistent with: A. Haemorrhagic disease of the newborn True/ False B. Factor X deficiency True/ False C. Factor XI deficiency True/ False D. Von Willebrand's disease True/ False E. Haemophilia C True/ False 9. Patients with thrombocytopenia, platelet function abnormalities, abnormal collagen and von Willebrand diseases are likely to have: A. Normal prothrombin time True/ False B. Abnormal bleeding time True/ False C. Normal bleeding time True/ False D. Normal activated partial thromboplastin time True/ False E. All of the above True/ False

10. The following are examples of qualitative disorders of platelets EXCEPT A. Bernard Soulier syndrome True/ False B. Glanzmans thrombasthenia True/ False C. Ataxia telangiectasia True/ False D. Chediak- Higashi Syndrome True/ False E. Ehlers–Danlos syndrome True/ False

11. Deficiency of Vit K has a negative effect on the coagulation factors EXCEPT for A. Prothrombin True/ False B. Factor X True/ False C. Factor V True/ False D. Factor VII True/ False E. Factor VIII True/ False

12. Activated partial thromboplastin time is prolonged in: A. Factor I deficiency True/ False B. Factor VIII deficiency True/ False C. Factor IX deficiency True/ False D. Von Willebrand disease True/ False E. Haemophilia A True/ False

13. Prothrombin time is normal in A. Thrombocytopenia True/ False B. Factor VII deficiency True/ False C. Factor VIII deficiency True/ False D. Haemophilia B True/ False E. Von Willebrand disease True/ False

14. The following are clinical manifestations or symptoms of thrombocytopenia A. Cutaneous purpura True/ False B. Haematoma True/ False C. Epistaxis True/ False D. Menorrhagia True/ False E. Haemarthroses True/ False

Answer 1

QUESTION 1. ________________is an indirect measure of platelet number and more direct measure of platelet function,vascular integrity,and platelet interaction with the vascular subendothelium.

ANSWER : (D) Bleeding Time

• Bleeding time is a type of medical test which is done on someone to assess their platelet function.
• Generally the normal bleeding time value run within the range between 2-9 minutes.But when the bleeding time value exceed more than 10 minutes , then the risk of bleeding increases.

QUESTION 2. Name three causes of thrombocytopenia?

ANSWER:

• Aplastic anemia, it is a type of blood disorder which affect the bone marrow.
• Leukemia , it is a type of cancer which damage the bone marrow.
• Thrombocytopenia also causes some virus such as mumps,rubella,HIV, chickenpox etc.

QUESTION 3. Heparin induced thrombocytopenia is associated with both ________________ and _____________

ANSWER : Heparin induced thrombocytopenia associated with both Type 1 HIT and Type 2 HIT

• Type 1 HIT occurs within the first two days after exposure to heparin and with the continued heparin therapy, the platelet count normalize.
• Type 2 HIT occurs within the 4 days to 10 days after exposure to heparin.It is a type of immune-mediated disorder.

QUESTION 4. Thrombotic thrombocytopenic purpura (TTP) as a cause of thrombocytopenia is caused by

ANSWER : Thrombotic thrombocytopenic purpura as a cause of thrombocytopenia is caused by deficiency of ADAMTS13 enzyme.

• ADAMTS13 enzyme is a type of protien in the blood which is involved in the blood clotting.
• The enzyme ADAMTS13 consist a large protein called von Willebrand factor.