Question

why are phosphodiesterase inhibitors high alert medication

Answer 1

Answer: The Phosphodiesterase inhibitors are used in the treatment of the pulmonary hypertension as well as erectile dysfunction. They work by inhibiting the cGMP which is the specific isoform 5 of phosphodiesterase. This causes reduction in the muscular tone.

This drug is considered to have major risk or may have severe reverse effects on the patient. It may cause cardiac inotropy up to extent. Nasal congestion could lead to reduced oxygen supply to the lungs and heart. It may increase the risk of other diseases.