Question

Medication Template:

Please answer the following questions for:

Medication: HYCAMTIN

Category Class: Antimitotics

Expected Pharmacological Action:

Therapeutic Use:

Complications:

Contraindications/Precautions:

Interactions:

Medication Administration:

Nursing Interventions:

Patient Education:

Evaluation of medication effectiveness:

Answer 1

Ans) Medication: HYCAMTIN

Category Class: Antimitotics

Expected Pharmacological Action:

- The working is due to double-strand DNA damage produced during DNA synthesis, when replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I, and DNA.

- kills the cancer cells & slows the disease progression.

Therapeutic use:

- Uses in small cell lung cancer

Complications:

- Toxicity includes bone marrow suppression, gastrointestinal complaints (diarrhea, nausea, constipation), stomatitis, and fatigue.

Contraindications and precautions:

- Hypersensitivity to hycamtin

Interactions:

- Avoid coadministration with Amoidarone, Acalabrutinib, Amoxicillin, claritromycin.

Medication administration:

- Recommended dose for injection is 1.5 mg/m2 by intravenous infusion over 30 minutes daily for 5 consecutive days, starting on Day 1 of a 21-day cycle until disease progression or unacceptable toxicity.

Nursing interventions:

- Assessment of the general condition, vital signs of the patient.

- Follow 10 rights of medication administration: Right patient, drug, dose, route, time, documentation, assessment education, evaluation, right to refuse.

- Report any signs and symptoms of complications.

Patient education:

- Explain the drug action & provide necessary contraindications and precautions.

- Teach the patient to identify and report any signs and symptoms of complications.

Evaluation of medication effectiveness:

- Blood test reports to show improvement

- Improvement in the general condition