Question

1. The ___________describes the relationship between the therapeutic dose of a drug (ED50) and the toxic dose of a drug (TD50).

Answer 1

The concentration of a drug in blood that range between the therapeutic drug dose at which the drug is effective and the lethal dose at which the drug cause toxicity is known as therapeutic drug index. If the drug has higher therapeutic index, the drug will be more safer to administer.

Therapeutic drug index is represent in ratio of LD₅₀:ED₅₀ where LD50 is the lethal dose at which the blood concentration of a drug can kill 50% of the test group and ED_{50 is} effective dose that produce desired effect in 50% of test group.

The answer is Therapeutic drug index.