Question

Atorvastatin

1what is the expected pharmacogical Action of Atorvasatatin

2. therapeutic use of Atorvastatin

3. complications/ precautions

4. interactions

5. evaluations

6. Evaluation of medication effectiveness

7. medication effectiveness

8. medication administration

9. nursing interventions

10. client education

Answer 1

1.Mechanism of Action

Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver. Atorvastatin also increases the number of LDL receptors on the surface of hepatic cells.

In patients with homozygous or heterozygous familial hypercholesterolemia, mixed dyslipidemia, isolated hypertriglyceridemia, or nonfamilial hypercholesterolemia, atorvastatin has been shown to reduce total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), very-low-density lipoprotein (VLDL-C) and triglycerides (TGs) while increasing high-density lipoprotein cholesterol (HDL-C).

2.Atorvastatin is used to reduce the levels of total blood cholesterol, low density lipoprotein (LD, Apoprotein (Apo)-B, and triglycerides. LDL is also referred to as "bad" cholesterol and Apo B is a marker for cardiovascular risk.

Atorvastatin also increases the levels of HDL cholesterol (good cholesterol) and helps prevent cardiovascular diseases. It is also approved for dysbetalipoproteinemia – a rare hereditary condition associated with elevated cholesterol and triglyceride levels.

3. Complications/Precautions. *Atorvastatin is complicated in pregnancy. *Dark color urine, ,fever, muscle cramps,pains , Indications of kidney problem due to atorvastatin.so we need to avoid this. *This may increase liver problem.