Question

pathophysiology of chronic low back pain?

Answer 1

Chronic lower back pain is caused by disorders of the intervertebral disk. Cytokines such as matrix, metalloproteinases , phospholipase A2 , nitric oxide and tumour necrosis factor -alpha are the causes or Etiology. hypertrophy of the facets and bony overgrowth of the vertebral endplates contribute to progressive foraminal and central canal narrowing. In addition to relative thickening of the ligament flavum and disk herniation, these changes contribute to reduction of the anteroposterior canal diameter and foraminal patency with neural compression. Spinal stenosis reaches a peak later in life and may produce radicular, myelopathic, or vascular syndromes such as pseudoclaudication and spinal cord ischemia. • degenerative disk disease • lack of exercise • prior injury • structural and postural abnormalities • systemic disease • obes