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This question is related to pharmacology what is the significance of the response curve being shifted...

This question is related to pharmacology

what is the significance of the response curve being shifted to the left of the binding curve for calcitonin receptors? How does a “receptor reserve” factor into this observation?

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Answer #1

Binding curve of calcitonin receptor was crucial for receptor- binding, whereas the. AC413/rAmy C-terminal ... antagonist concentration that right-shifts the agonist concentration-response curve by two- fold.

Receptor reserve (spare receptors): This refers to the condition in a tissue whereby the agonist needs to activate only a small fraction of the existing receptor population to produce the maximal system response. The magnitude of the reserve depends upon the sensitivity of the tissue and the efficacy of the agonist.

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