Question

What were the five limitations to the PROSEVA trial?

Answer 1

PROSEVA :

Prone positioning in severe acute respiratory Distress syndrome.

In the Proning severe ARDS(PROSEVA trial) patients with severe ARDS who are mechanically ventilated were randomised to either prone positioning for 16hours or left in supine position.

PROSEVA Trial in ARDS has shown improved oxygenation and significantly reduced mortality rate when compared with patients remaining in supine position.

Proned patients were extubated at higher rates and they required fewer days of ventilation support when compared to supine patients.

Five limtations to PROSEVA Trial:

​​​​​​There are some limitation for Proning in Severe ARDS(PROSEVA Trial)

1)Patients with Burns or open wounds on the face or ventral body surface.

2)Patients with Spinal instability,Pelvic fractures,Femur fracture

3)Increased intracranial pressure & intraocular pressure

4)Recent Sternotomy/Cardiac surgery/Peritoneistomy

5)Severe Arrhythmias